Here, using large-scale gene expression profiling of more than 450,000 single cells, the team demonstrated that most cells in the motor cortex have conserved counterparts in all three mammal species. Examining gene expression at the single-cell level provided locations for cell types within the motor cortex to create an atlas, and how specific gene activity dictated neuron characteristics, such as their physiological and anatomical properties.Ī detailed comparison of these species was reported in the study, “ Comparative cellular analysis of motor cortex in human, marmoset, and mouse.” This work revealed an interconnected genetic landscape of cell types that integrated their gene expression (activity), as well as commonalities of gene expression that are similar from mouse to marmoset and human. Researchers examined the activity of a complete set of genes within cells and where they are located, the three-dimensional shape of the cells, their electrical properties, and how they connect to neighboring cells. They then used a variety of methods to measure the properties of individual cells. In the consortium’s flagship study, “ A multimodal cell census and atlas of the mammalian primary motor cortex,” scientists first divided the millions of neurons and other cell types of the motor cortex into different categories. “Once we have created a catalogue of all cell types that together form our brains, we can learn more about how they interact with each other in a system.” Tabular material in separate pages and additional supporting material as a part of the electronic companion so the printed page stays focused on the illustration.“In order to understand how the brain works and what goes wrong when we suffer from disease, we need to start by looking at the brain’s most important building blocks, the cells,” Linnarsson said.Large, clear illustrations with comprehensive labels not only of major structures, but also of those with important relationships.Region-by-region coverage, including Muscle Table appendices at the end of each section.In addition, more than 50 carefully selected radiologic images help bridge illustrated anatomy to living anatomy as seen in everyday practice.
Together, these two uniquely talented physician-artists highlight the most clinically relevant views of the human body. Machado, one of today’s foremost medical illustrators. Frank Netter, you’ll also find nearly 100 paintings by Dr. The only anatomy atlas illustrated by physicians, Atlas of Human Anatomy, 7th edition, brings you world-renowned, exquisitely clear views of the human body with a clinical perspective.